The biggest college football matchup in Week 2 pits the Michigan Wolverines against the Oklahoma Sooners, and I've worked it into a +318 parlay.
The pregame narrative: No. 15 Michigan hits the road to face No. 18 Oklahoma in Saturday's only ranked-on-ranked battle. Both teams boast talented defences that could turn the game into a slog.
Check out my college football parlay predictions for Week 2, featuring a pick on the Akron Zips vs. Nebraska Cornhuskers game.
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College football predictions: Week 1 parlay
Parlay: Michigan/Oklahoma under 48.5 points | Nebraska -27.5 | Sam Houston/Hawaii over 47.5 points (+318)
Michigan/Oklahoma under 48.5 points (-152): I'm banking on two supremely talented defences to win out in this one.
- Both defences ranked in the top 12 in yards per rush last year. They also both ranked inside the top 40 in EPA per play, according to Game On Paper.
- Michigan returned five defensive starters and brought in two four-star defensive line transfers from the portal. The Wolverines have finished in the top 20 in EPA per play in eight of the past 10 seasons.
Oklahoma quarterback John Mateer might be the real deal, but the Washington State transfer isn't used to facing a defence like this.
On the other side, Michigan's five-star true freshman quarterback, Bryce Underwood, will be in a hostile road environment for the first time. Facing a defence with nine upperclassmen starters, I expect him to struggle.
NCAAF parlay picks
Nebraska -27.5 (-295): Akron lost 10-0 at home last week in its season opener. This is a bottom-of-the-barrel NCAA Division I program.
Last year, Akron ranked 125th among 134 schools in EPA per play. Against three Power 4 schools in non-conference play, the Zips were outscored by 121 points and failed to cover a +27.5 spread each time.
Nebraska quarterback Dylan Raiola (33 of 42, 245 yards, two TDs) was solid in the season opener. He connected in the end zone with both of the Huskers' four-star transfer wideouts, Dane Key and Nyziah Hunter.
Raiola should have the offence humming against an Akron squad that allowed 42.8 PPG in non-conference play last year.
Sam Houston/Hawaii over 47.5 points (-114): The Sam Houston Bearkats had a strong defence a year ago, but things have changed drastically in 2025.
None of the Bearkats' defensive starters returned, and they entered the year with just four players having 110+ FBS snaps a season ago.
The early returns for the completely remade group are ... not good.
Sam Houston has allowed 910 yards and 79 total points through two games, losing to Western Kentucky and UNLV in the process. Both games soared past this total.
I'm hoping some of that defensive ineptitude sparks something for Micah Alejado and the Hawaii Warriors, who've been sluggish out of the gate.
Both of Hawaii's games went under this total, albeit not by much (43 points, 46 points). Alejado already has 70 pass attempts, so you know the Warriors are looking to sling it.
Sam Houston's first two opponents combined for 650 passing yards, five TDs and a 70.3% completion rate.
College football predictions made at 1:30 p.m. on 09/03/2025.
