The Los Angeles Rams are off to a strong start and should be dangerous against the reigning Super Bowl champions in Week 3.
The pregame narrative: L.A. nearly downed the Philadelphia Eagles in the playoffs last season, and now the Rams return to Philly with another shot at an upset win. The Rams are 4-point underdogs after a very comfortable road win over the Titans.
Check out my top Week 3 NFL upset picks, featuring a pick on the Detroit Lions vs. Baltimore Ravens matchup.
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NFL upset picks: Week 3
Best bet: Rams moneyline (+175)
The Rams came tantalizingly close to derailing the Eagles' Super Bowl run in the NFC divisional round last year.
On a snowy afternoon in Philadelphia, the Eagles escaped with a 28-22 win. Los Angeles had the ball in the red zone with under two minutes to play before turning it over on downs.
Matthew Stafford threw for 324 yards in that game despite playing with sore ribs. There were injury concerns surrounding Stafford ahead of this season, too, but he's done well to quiet his critics.
Stafford has completed 44 of 62 passes (71.0%) for 543 yards through two games. That equates to a 107.1 passer rating, which is seventh in the NFL.
Competent quarterback play is a must for underdogs entering hostile environments, and the 17-year vet certainly provides that.
On the defensive side, L.A. has impressively handled its business. The Rams' defence ranks No. 2 in EPA per play and success rate, per RBSDM.com.
Philadelphia was a bit shaky in its home opener vs. Dallas before earning a solid win in a Super Bowl rematch in Kansas City this past week. Still, its two victories are by a combined seven points.
Los Angeles is 2-0 ATS, winning its first two games by a combined 19 points.
Key stat: Last season, the Rams went 5-6 straight up as underdogs, per Team Rankings.
NFL underdog predictions
Lions moneyline (+210): The Lions and Ravens have followed the same path so far this season.
After losing on the road against Super Bowl contenders in Week 1, both teams followed up with dominant home wins in Week 2.
Baltimore definitely has the advantage in this one as the home team, but Detroit is still one of the best squads in the NFL. One poor outing against the ferocious Green Bay Packers hasn't changed my mind about that.
With each passing week, the Lions grow more familiar with life after Ben Johnson and Aaron Glenn — the offensive and defensive coordinators who moved on for head coaching gigs.
Let's not forget how much talent those coordinators left behind in the Motor City.
Detroit ranked No. 1 in scoring offence and No. 7 in scoring defence, and neither unit lost any key playmakers.
The Lions were only underdogs twice last year. It's a rarity these days, but they still tend to thrive in that role when given the chance.
Since 2022, Detroit is 7-10 SU as an underdog.
NFL upset picks made at 10:07 a.m. ET on 09/15/2025.
