I'm backing one running back, one wide receiver and one quarterback to score on Monday Night Football.
The pregame narrative: Rookie Omarion Hampton had a huge workload for the Los Angeles Chargers in his debut, and he holds value to score against the Las Vegas Raiders. Before that, Nico Collins and Baker Mayfield are my picks when the Houston Texans host the Tampa Bay Buccaneers.
Check out my top anytime touchdown scorer picks for the Week 2 MNF doubleheader on Sept. 15.
BET FINDER: Search & Bet!
Anytime touchdown scorer picks
Best bet: Hampton to score a TD (-118)
Jim Harbaugh loves to run the football, so when he spent the 22nd overall pick in the 2025 NFL Draft on Hampton, it was clear he was going to use him.
The North Carolina Tar Heels product didn't have the most efficient NFL debut, turning 17 touches into 61 yards.
But he did log a monster 80% snap count, with backup RB Najee Harris receiving just one carry.
That type of usage has my attention, and it should have yours, too.
Los Angeles' offence put up 27 points in Week 1 against a Kansas City Chiefs team that just held the Philadelphia Eagles to 20. None of its three TDs came on the ground, but that's bound to change.
I love the Chargers to cover as 3.5-point road underdogs tonight, and expect fireworks from Hampton.
In his final year of college, Hampton scored 17 touchdowns in 12 games with the Tar Heels.
Ket Stat: Los Angeles had the 10th-highest rushing play percentage in 2024 (44.91%).
Buccaneers vs. Texans TD picks
Collins to score a TD (+133): Collins was a non-factor in Week 1, logging just three catches for 35 yards.
I'll plug my nose and throw that result out.
The star wideout was elite when on the field last year, posting some gaudy numbers on a per-game basis (regular season and playoffs):
- 86.4 receiving yards/game
- 8.2 targets/game
- 1+ TD in seven of 14 games
Collins had a 28.3% red zone target share during the regular season, which ranked 11th in the NFL, per Player Profiler.
He also ranked in the top 10 in catches of 30-plus yards, 40-plus yards, and 50-plus yards, despite missing five games with an injury.
Whether it's a home run play or a goal-line read, C.J. Stroud should be looking Collins' way.
Mayfield to score a TD (+650): This is worth a flier given how often Mayfield runs the ball.
The Bucs' quarterback turned five carries into 35 yards in his opener, and logged 378 rushing yards and three scores last season — both career highs.
The Texans gave up the 11th-most rushing yards to QBs last year at 6.66 yards per carry.
Bucky Irving will get the vast majority of red zone looks, but I could see Mayfield breaking loose on a bootleg for a score.
Anytime touchdown scorer picks made at 10:32 a.m. ET on 09/15/2025.
