Top European soccer leagues return to action after a week off for an international break.
The pre-weekend narrative: On Saturday, Real Madrid aims to maintain its perfect season when it battles Real Sociedad. On Sunday, Manchester United visits Manchester City for an exciting derby match, where the visitors are priced as a sizable underdog.
Check out this weekend's best European soccer predictions for games beginning on Sept. 13, 2025, featuring a pick on Fiorentina vs. Napoli.
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Soccer predictions
Manchester City vs. Manchester United (Sept. 14, 11:30 a.m. ET)
Best bet: Manchester United to win or draw (+110)
There are a couple of things working against Man U in this matchup, so let's get those negatives out of the way.
- Man City will play this contest at home, and home-field advantage is important in soccer.
- In terms of results, United hasn't been the best. The Red Devils are 1-1-1 this season.
The side arguably deserved better on the road vs. Arsenal on Matchday 1, however. It outshot the Gunners 22-9 and controlled the possession in the 1-0 loss.
But things haven't been any better for the Citizens. Man City has one win and two losses, with the lone victory coming against last-place Wolverhampton.
In its only home game, Tottenham came into Etihad Stadium and stifled Manchester City 2-0.
This should be an even match, and that puts the value with the almost 4-to-1 underdog.
Key stat: Despite getting off to a mediocre start, Manchester United leads the EPL with 6.8 xG through three games.
La Liga best bet
Matchup: Real Sociedad vs. Real Madrid (Sept. 13, 10:15 a.m. ET)
Real Madrid to win (-148): This is a steep price, but Real Madrid has the right matchup to improve to 4-0-0.
- Through three matches, Madrid has scored six goals while only conceding once.
- Sociedad is 0-2-1 without playing any top teams to this point.
According to Fotmob, Real Madrid has the highest average match rating going into this weekend (7.45).
The only thing working against Los Blancos is that they're on the road. But if you can get past that, there is still value on the best team in Spain winning on Saturday.
Serie A prediction
Matchup: Fiorentina vs. Napoli (Sept. 13, 2:45 p.m. ET)
Napoli to win (+125): That makes three away sides that I'm betting on this weekend, but Napoli is too good to be priced at plus money.
After two matches, Napoli is 2-0-0 and has yet to concede.
On the other side, Fiorentina has tied two bottom-half teams in Cagliari and Torino. Both of which are likely to be in the relegation picture this season.
Fiorentina has scored one goal so far this season and should struggle to break down Napoli's defence.
The Serie A leaders have conceded 0.9 xG and scored three goals in two matches.
Soccer predictions made at 1:13 p.m. on 09/10/25.
