Favourites reigned supreme during the first week of NFL action, going 11-4 SU, but I've got my eyes on two upsets for the upcoming slate.
The pregame narrative: The San Francisco 49ers are already dealing with significant injuries, and they now head cross-country to play the Saints in New Orleans. This feels like a spot where Spencer Rattler and Co. can steal a win.
Check out my top Week 2 NFL upset picks, featuring a pick on the New England Patriots vs. Miami Dolphins.
BET FINDER: Search & Bet!
NFL upset picks: Week 2
Best bet: Saints moneyline (+175)
New Orleans isn't projected to win many games this season, but I was impressed with the fight its defence put up against the Arizona Cardinals in Week 1.
- The Saints' defence held Arizona to 276 yards in the game and just three points in the second half.
- Outside of a 52-yard run by Trey Benson, the Cardinals put up just 94 rushing yards on 3.48 yards/carry.
- New Orleans' 28.0% defensive rush success rate was the fifth-best among all teams, per RBSDM.com.
It's no secret San Francisco is going to want to run the ball on Sunday, but I'm skeptical it'll be able to do that effectively.
Christian McCaffrey toted the ball 22 times for an inefficient 69 yards in Week 1 against the Seattle Seahawks. He'll be asked to do more with George Kittle out and Brock Purdy (toe/shoulder) questionable.
If Purdy can't go, backup Mac Jones will be under centre, and this line will surely move a few points in New Orleans' direction.
Key stat: San Francisco ranked 27th in offensive EPA per rush in Week 1.
NFL underdog predictions
New England moneyline (+105): New England is barely an underdog against Miami, but it's an underdog nonetheless.
The Dolphins will be back home in Week 2, but I can't put any faith in a team that was just dismantled by the Daniel Jones-led Indianapolis Colts.
Miami was down 30-0 into the dying minutes of the fourth quarter before scoring a garbage-time touchdown to avoid a shutout.
It looks like the team has already quit on fourth-year head coach Mike McDaniel and quarterback Tua Tagovailoa.
The Patriots are far from a good team, mind you. But I trust Mike Vrabel to get his group going against a divisional rival.
NFL upset picks made at 11:57 a.m. ET on 09/09/2025.
