Our staff's Week 2 best bet recommendations feature three ATS picks, one moneyline wager, and two player props.
The Week 2 narrative: Joe Burrow and the Cincinnati Bengals look to snap a bizarre streak of Week 2 losses and are favoured at home against the Jacksonville Jaguars. Elsewhere, look for Justin Fields to back up his stellar New York Jets debut with another strong performance.
Check out our NFL Week 2 staff best bets for our favourite picks this weekend.
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NFL Week 2 best bets
These NFL Week 2 best bets were provided by NorthStar Bets writers Avery Perri, Spencer Closs and Jordan Horrobin.
ATS picks
Cowboys -6 (-110): The New York Giants didn't show much promise in Week 1, losing 21-6 against the Washington Commanders.
Russell Wilson completed less than 50% of his passes for 168 yards, and the running backs combined for a measly 30 yards on 10 rushes.
The Cowboys, on the other hand, were competitive against the Philadelphia Eagles and had a legit chance to win on the road. Now, Dallas gets a worse opponent at home, where Dak Prescott is 43-18 in his career.
-Closs
Eagles -1.5 (-112): I get that it's a road game for the Eagles, but I really don't think the reigning champions should have this tight of a line in the Super Bowl rematch.
Philadelphia steamrolled the Kansas City Chiefs in February, scoring the first 34 points of a 40-22 victory. Week 1 wasn't a great showing for the Eagles, but they still came away with a divisional win. The Chiefs, meanwhile, fell to the Chargers as 3-point favourites.
The Eagles are largely the same team as last year, they have an extra day of rest, and they're facing a Chiefs offence that could be missing Xavier Worthy (in addition to the suspended Rashee Rice).
-Horrobin
Bengals -3.5 (-110): Burrow has never won a game in Week 2, and Cincinnati looked awful in its opener. But I’m betting on his larger body of work and expect an end to this bizarre trend.
The Bengals were top-10 in total offence, scoring offence, and offensive EPA per play last year, according to RBSDM.com. Jacksonville, meanwhile, ranked last in defensive EPA per pass and went 4-13 with zero wins against playoff teams.
I’m not putting any stock into Jacksonville's win over the Carolina Panthers in Week 1. Cincinnati is the far better team and should roll.
-Perri
Best moneyline bet
Broncos ML (-120): I'm not interested in overreacting to Week 1, so Daniel Jones and the Indianapolis Colts will have to do more than beat up on the Miami Dolphins to impress me.
Denver was a top-10 scoring team on both sides of the ball in Bo Nix's rookie year, and the team is expected to be a feisty playoff-calibre squad again. The Broncos are 9-0 SU as favourites since the start of last year.
Nix threw three interceptions in a Week 15 matchup vs. the Colts last year, but the Broncos still emerged with a 31-13 victory.
-Horrobin
NFL Week 2 best bets: Player props
Javonte Williams over 54.5 rushing yards (-114): Dallas used Williams early and often against Philadelphia in Week 1, as the newly-acquired running back turned 15 rushes into 54 yards and two TDs.
Was it the most efficient performance? No, but Philly owns one of the best run defences in football, and the same can't be said for New York.
The Giants allowed the sixth-most rushing yards per game last season and ceded 220 at 6.9 YPC to the Washington Commanders in Week 1.
No other Cowboys RB had more than four carries in the opener, so I expect Williams to have a healthy workload.
-Perri
Fields over 43.5 rushing yards (-117): Fields looked electric in his New York Jets debut, throwing efficiently while rushing for 48 yards and two touchdowns.
The Jets have the game script to hurt the Buffalo Bills' defence, courtesy of the Baltimore Ravens last week: A heavy dose of RPOs with Breece Hall and Fields.
I'm not saying that duo is Derrick Henry and Lamar Jackson, but it's not so far off.
Buffalo gave up 238 rushing yards in Week 1 — 70 to Jackson — and got gashed by Patrick Mahomes for 43 rushing yards in last year's AFC championship game.
The Bills' run defence is sieve-like, and Fields has the speed to clear this on a few chunk plays.
-Perri
NFL Week 2 best bets made at 12 p.m. ET on 09/11/2025.
