One down... 17 more to go! The NFL season heads into its second week with a handful of Grade-A matchups for bettors to target.
Week 2 at a glance: A Super Bowl rematch between the Philadelphia Eagles and Kansas City Chiefs at Arrowhead Stadium headlines the slate. Elsewhere, Aaron Rodgers makes his Pittsburgh Steelers home debut, and the Minnesota Vikings are back in primetime for the second straight week.
Check out our Week 2 NFL betting guide, featuring staff picks and predictions for the loaded 16-game slate.
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NFL betting guide
Key storylines:
- Kansas City's three-peat hopes were squashed by Philadelphia last season in a blowout of epic proportions. The Chiefs lost their season-opener and now have a gut-check moment at home against the defending champs. Philly is a 1.5-point road favourite as of Thursday morning.
- The Green Bay Packers put the NFL on notice, blowing out the Detroit Lions in Week 1. The Micah Parsons-led defence held Detroit to 246 yards and zero touchdowns outside of garbage time.
- Rodgers still has it, huh? The four-time MVP dazzled in his Steelers debut, throwing for 244 yards and four touchdowns in a win. Now, he'll be tasked with dissecting a strong Seattle Seahawks defence at Acrisure Stadium.
- Justin Fields went blow-for-blow with Rodgers in his New York Jets debut, scoring three total touchdowns with a 119.1 passer rating. Now he'll have a chance to pull off an upset against the Buffalo Bills, who allowed 40 points in Week 1.
- Speaking of the Bills, they authored an epic 16-point comeback behind Josh Allen at Highmark Stadium last week to leave the Baltimore Ravens stunned. The result? Buffalo is atop the Super Bowl odds board and Allen is favoured to win MVP.
- There will be no quarterback change for the New York Giants... yet. Russell Wilson looked immobile and inaccurate in a 21-6 loss to the Washington Commanders, but head coach Brian Daboll is sticking with him in Week 2. Rookie QB Jaxson Dart is waiting in the wings, though.
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NFL Week 2 betting notes
- Joe Burrow and the Cincinnati Bengals barely won their opener and failed to cover. Cincinnati is now 2-9 straight up and 3-8 against the spread in Weeks 1 and 2 with Burrow under centre. The Bengals are a slight favourite over the Jacksonville Jaguars (1-0).
- Are shortened preseasons to blame for a lack of offence? Unders went 12-4 in Week 1 with an average of just 41.3 points per game. Ten games this week have a total set at or above 44 points.
- Since 2005, teams that lost in Week 1 and are underdogs in Week 2 have gone a stellar 101-75-4 (57%), according to Bet Labs.
- Kansas City falls into that category. The Chiefs are 22-5 SU following a loss and 12-2-1 ATS as an underdog with Patrick Mahomes.
- Jared Goff and the Lions have won and covered in 10 straight games following a loss dating back to November 2022. They're favoured at home against the Bears this week.
- Dak Prescott has won 13 straight games against the Giants, and has a career 10-5 ATS record against his divisional foes.
- Who will step up for KC with Xavier Worthy (shoulder) injured and Rashee Rice suspended? Marquise "Hollywood" Brown caught 10 of a league-high 16 targets in Week 1. He should have a healthy workload against the Eagles.
Biggest spreads: Browns vs. Ravens (-11.5), Panthers vs. Cardinals (-6.5), Bills (-6.5) vs. Jets
Highest totals: Jaguars vs. Bengals (49), Commanders vs. Packers (48.5), Bears vs. Lions (47)
NFL betting guide: Week 2 predictions
NFL Week 2 prop picks: The Seahawks' backfield could be a true timeshare situation, but Zach Charbonnet was the better half in Week 1. Find out what Perri expects of him this Sunday, along with predictions on Marvin Harrison Jr. and Travis Hunter.
NFL Week 2 ATS picks: Get ATS predictions for the entire slate, headlined by Eagles vs. Chiefs in a Super Bowl rematch on Sunday afternoon.
NFL Week 2 upset picks: No team looked worse than the Miami Dolphins in Week 1, yet they're favoured this coming Sunday. Perri is fading them and also has his eyes set on a +175 underdog.
NFL Week 2 best bets: Any Justin Fields truthers out there? One of his prop markets is featured in our staff picks, along with an ATS bet on the Bengals. All in, there are three ATS plays, two player props and a moneyline prediction.
NFL Week 2 TD picks: Tee Higgins was a red zone monster last year, and he faces one of the worst secondaries in football. Read more about his matchup, and find two other players with value north of 2-to-1 to score.
Bills vs. Jets SGP picks: If you're a fan of strong receiver play, this parlay from Closs is for you. His +375 ticket features prop bets on Keon Coleman and Garrett Wilson.
Eagles vs. Chiefs SGP picks: Perri is keen on backing Mahomes as an underdog and is teasing the Chiefs up a few points for safety. His +300 SGP also features wide receivers Hollywood Brown and DeVonta Smith.
Falcons vs. Vikings picks: It took a while, but Justin Jefferson and J.J. McCarthy eventually clicked in their first game today. Jefferson is Horrobin's primary target for his Sunday Night Football best bet, along with a prediction on the game total.
Buccaneers vs. Texans picks: C.J. Stroud has been much better at home than on the road in his young career, and that trend will be put to the test again in prime time. After a 14-9 road loss to the Rams last week, Stroud's Texans are favoured over the four-time reigning NFC South champion Buccaneers.
Falcons vs. Vikings SGP picks: Bijan Robinson had 100 yards receiving in Week 1, but Closs is backing him on the ground on Sunday Night Football. His +310 SGP features the star running back and quarterback J.J. McCarthy.
Chargers vs. Raiders picks: Herbert and the Chargers upset the Chiefs in Brazil and now can go 2-0 in divisional games to start the season. See why Horrobin expects Herbert and L.A. to have another big showing on Monday.
Falcons vs. Vikings TD picks: Psihogios is backing a pair of top receivers on Sunday Night Football. Find out why he's backing Justin Jefferson and Drake London.
Buccaneers vs. Texans SGP picks: This +300 SGP features a pick on quarterback C.J. Stroud. See why Closs believes the QB will lead Houston to their first win at home.
Chargers vs. Raiders SGP picks: Geno Smith threw 362 yards in his debut with Las Vegas, and Psihogios likes the veteran to have another big performance. Check out his +360 SGP for Monday Night Football.
NFL Week 2 matchups
Thursday Night Football (Sept. 11)
- Commanders vs. Packers (8:15 p.m. ET)
Sunday, Sept. 14: 1 p.m. ET slate
- Seahawks vs. Steelers | Rams vs. Titans | Bills vs. Jets | Bears vs. Lions | Patriots vs. Dolphins
- Giants vs. Cowboys | Browns vs. Ravens | 49ers vs. Saints | Jaguars vs. Bengals
Sunday, Sept. 14: 4 p.m. ET slate
- Panthers vs. Cardinals | Broncos vs. Colts | Eagles vs. Chiefs
Sunday Night Football
- Falcons vs. Vikings (8:20 p.m. ET)
Monday Night Football doubleheader (Sept. 15)
- Buccaneers vs. Texans (8:15 p.m. ET)
- Chargers vs. Raiders (10:00 p.m. ET)
