Another full slate of NFL action is on tap in Week 2, and our staff has against-the-spread predictions for every game.
The Week 2 narrative: Aside from the Baltimore Ravens' hefty spread at home against the Cleveland Browns, every game this week is projected to finish within a touchdown. That includes the Super Bowl rematch in Kansas City, a matchup that sparked some disagreement among our writers.
Check out our staff's Week 2 NFL ATS picks for predictions on every game.
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NFL ATS picks: Week 2
NorthStar Bets' Avery Perri, Jordan Horrobin, Spencer Closs, Chris Toman, and Steven Psihogios offer up their Week 2 NFL ATS picks for all 16 games.
NFL odds as of 11:15 a.m. ET on Thursday, Sept. 11, 2025.
Thursday Night Football pick
Commanders vs. Packers (Thursday, Sept. 11: 8:20 p.m. ET)
NorthStar Bets line: Packers -3
Horrobin says: Green Bay bullied the NFC's reigning No. 1 seed, the Detroit Lions, in last week's opener. Micah Parsons is still ramping up and should be more of a factor in Week 2. In the trenches on the flip side, look for the Packers to impose their will in the ground game. Since the start of 2024, Green Bay ranks eighth in offensive EPA per rush, according to RBSDM.com, while Washington is 29th in defensive EPA per rush.
Staff picks: Perri (WSH) | Horrobin (GB) | Closs (GB) | Toman (WSH) | Psihogios (WSH)
NFL ATS picks: The early Sunday slate
Bills vs. Jets (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: Bills -6.5
Perri says: Buffalo really had no business winning in Week 1, but Josh Allen did what Josh Allen does, and the rest is history. I can't look past Buffalo's horrendous rush defence, which was gashed by Lamar Jackson and Derrick Henry. New York has a similar attack and is 2-1 against Buffalo in the last three matchups at MetLife Stadium (3-0 ATS).
Staff picks: Perri (NYJ) | Horrobin (NYJ) | Closs (BUF) | Toman (BUF) | Psihogios (BUF)
Bears vs. Lions (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: Lions -6
Horrobin says: Caleb Williams looked less and less comfortable as Chicago’s season opener wore on, and ultimately, he couldn’t help his team maintain a two-score lead in the fourth quarter. Going to Detroit, where the Lions will be hungry to erase last week’s dud in Green Bay, I expect the home team to be at least a touchdown better than the Bears. Detroit has the NFL’s best ATS record since the start of the 2023 season (26-13-0).
Staff picks: Perri (DET) | Horrobin (DET) | Closs (CHI) | Toman (CHI) | Psihogios (DET)
Browns vs. Ravens (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: Ravens -11.5
Closs says: The Browns had the chance to upset the Bengals in Week 1, but the offence failed to muster more than 16 points against what is expected to be a weak Cincinnati defence. That won't fly against the Baltimore. The Ravens lost a heartbreaker to the Bills but scored 40 points behind 169 rushing yards from Derrick Henry. Baltimore played Cleveland in Week 18 last season and won by 25. I expect much of the same this time around.
Staff picks: Perri (BAL) | Horrobin (BAL) | Closs (BAL) | Toman (BAL) | Psihogios (CLE)
Jaguars vs. Bengals (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: Bengals -3.5
Perri says: Joe Burrow has never won a Week 2 game, but I expect that bizarre trend to end on Sunday. The Bengals were top-10 in total offence, scoring offence, and offensive EPA per play last year. The Jags, meanwhile, ranked last in defensive EPA per pass and beat zero playoff teams. Cincinnati is the better team and should roll at home.
Staff picks: Perri (CIN) | Horrobin (JAX) | Closs (CIN) | Toman (JAX) | Psihogios (JAX)
Rams vs. Titans (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: Rams -5.5
Toman says: Tennessee only managed 12 points in Week 1, but covered. The Rams only scored 14 points in Week 1, but covered. Los Angeles took down the Texans, 14-9, improving to 11-4 ATS over its last 15 games. Titans QB Cam Ward had a difficult task in his first NFL game against the Broncos’ elite defence, and his home debut should present similar challenges.
Staff picks: Perri (TEN) | Horrobin (TEN) | Closs (TEN) | Toman (LAR) | Psihogios (TEN)
Patriots vs. Dolphins (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: Dolphins -1
Toman says: These teams combined for 21 points in Week 1. The Dolphins turned in probably the worst performance of the week, with a nonexistent passing game behind Tua Tagovailoa. Looking for positives? De’Von Achane ran the ball well in limited opportunities, and Miami returns home to face a Patriots team that got carved up through the air last Sunday. Give me the home side.
Staff picks: Perri (NE) | Horrobin (MIA) | Closs (MIA) | Toman (MIA) | Psihogios (NE)
Giants vs. Cowboys (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: Cowboys -5.5
Closs says: Russell Wilson completed 45.9% of his passes (17/37) for 168 yards en route to six points for the Giants in Week 1. The Cowboys almost stole a win over Philadelphia last Thursday and get a worse opponent in Week 2 at home, where Dak Prescott is 43-18 in his career. I think Dallas easily covers a touchdown.
Staff picks: Perri (DAL) | Horrobin (DAL) | Closs (DAL) | Toman (DAL) | Psihogios (DAL)
49ers vs. Saints (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: 49ers -3
Perri says: San Francisco is already dealing with some substantial injuries, with Brock Purdy doubtful and George Kittle out. That means we're likely getting a Mac Jones vs. Spencer Rattler showdown. Yikes. In this case, I'll back the home underdog to keep things close. New Orleans' rush defence was excellent in Week 1, and I'm hoping it can bottle up Christian McCaffrey.
Staff picks: Perri (NO) | Horrobin (NO) | Closs (NO) | Toman (NO) | Psihogios (NO)
Seahawks vs. Steelers (Sunday, Sept. 14: 1 p.m. ET)
NorthStar Bets line: Steelers -3
Perri says: Aaron Rodgers was slinging it in his Steelers debut, throwing for 244 yards and four TDs. His 136.7 passer rating was the best from a Pittsburgh QB since 2017. At home, I expect him to keep the ball moving against Seattle. I can't say the same for Sam Darnold, whose offence generated just 230 total yards against San Fran last week.
Staff picks: Perri (PIT) | Horrobin (PIT) | Closs (PIT) | Toman (SEA) | Psihogios (PIT)
NFL 4 p.m. slate
Panthers vs. Cardinals (Sunday, Sept. 14: 4:05 p.m. ET)
NorthStar Bets line: Cardinals -6.5
Horrobin says: Even with a garbage-time score, Bryce Young’s stat line in Week 1 (18 of 35, 154 yards, one TD and two INTs) was hideous. He’ll be on the road again this week, and I have no faith in a better result. Arizona, which covered this number in its season-opening win, is 11-6 ATS at home since the start of last year.
Staff picks: Perri (ARI) | Horrobin (ARI) | Closs (ARI) | Toman (ARI) | Psihogios (CAR)
Place your bets on the 4 p.m. NFL slate
Broncos vs. Colts (Sunday, Sept. 14: 4:05 p.m. ET)
NorthStar Bets line: Broncos -1.5
Horrobin says: Bo Nix threw three interceptions in last year’s Week 15 matchup against the Colts … and the Broncos still won by 18 points. I’m not letting one strong showing from Daniel Jones steer me away from a Broncos squad that excelled on both sides of the ball last year. Since the start of the 2024 season, Denver is 9-0 SU as a favourite and has covered this number each time.
Staff picks: Perri (DEN) | Horrobin (DEN) | Closs (DEN) | Toman (DEN) | Psihogios (DEN)
Eagles vs. Chiefs (Sunday, Sept. 14: 4:25 p.m. ET)
NorthStar Bets line: Eagles -1.5
Horrobin says: Philadelphia dominated KC in the Super Bowl six months ago (40-22 final), and I don’t think the reigning champs could roll again in the rematch. Neither team was at its best in Week 1, but at least Philly scratched out a win while Kansas City lost as a 3-point favourite. The Eagles have an extra day of rest, and Xavier Worthy is at serious risk of missing this game.
Staff picks: Perri (KC) | Horrobin (PHI) | Closs (PHI) | Toman (KC) | Psihogios (PHI)
Sunday and Monday Night NFL ATS picks
Falcons vs. Vikings (Sunday, Sept. 14: 8:20 p.m. ET)
NorthStar Bets line: Vikings -3.5
Perri says: J.J. McCarthy came through when it mattered on Monday, but it was really Chicago that threw the game away. I like Atlanta's roster and trust Micahel Penix Jr. to keep things close on the road. The Vikings are missing some offensive firepower, so I think a field goal plus a hook is fairly safe.
Staff picks: Perri (ATL) | Horrobin (MIN) | Closs (ATL) | Toman (ATL) | Psihogios (ATL)
Buccaneers vs. Texans (Monday, Sept. 15: 7 p.m. ET)
NorthStar Bets line: Texans -2.5
Toman says: C.J. Stroud closed out last season on a rough note and he picked up where he left off in Week 1. It was an ugly start for Stroud and the Texans, who continue to be levelled by injuries. I can’t get behind this team as a favourite against anyone good. The Bucs pulled off an impressive win on the road in Week 1 and I like them to do it again on Monday night.
Staff picks: Perri (TB) | Horrobin (TB) | Closs (HOU) | Toman (TB) | Psihogios (HOU)
Chargers vs Raiders (Monday, Sept. 15: 10 p.m. ET)
NorthStar Bets line: Chargers -3.5
Closs says: I'm high on Los Angeles after its win against the Chiefs in Brazil. Justin Herbert looked elite, passing for 318 yards and three TDs. Plus, the defence held Kansas City to 21 points. The Raiders beat the Patriots by a touchdown in Week 1 but looked average at best. They should be comfortably outmatched at almost every position in Week 2.
Staff picks: Perri (LAC) | Horrobin (LAC) | Closs (LAC) | Toman (LAC) | Psihogios (LV)
NFL ATS picks, Week 1: Toman: 10-6 | Perri: 9-7 | Horrobin: 8-8 | Psihogios: 8-8 | Closs: 6-10
