The NFL is back! Football fans are being treated to four primetime matchups in Week 1 and wall-to-wall action on Sunday.
Week 1 at a glance: The NFL is coming out swinging. Josh Allen and the Buffalo Bills vs. Lamar Jackson and the Baltimore Ravens. The revamped Green Bay Packers vs. the loaded Detroit Lions. And Aaron Rodgers is making his Pittsburgh Steelers debut against the team that released him, the New York Jets.
Check out our Week 1 NFL betting guide, featuring staff picks and predictions for the loaded 16-game slate.
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NFL betting guide
Key storylines:
- Jerry Jones loves it when his Dallas Cowboys are in the spotlight. Well, he got his wish after trading three-time All-Pro pass rusher Micah Parsons to the Packers. The result? Green Bay is favoured against Detroit, which won a league-high 15 games last year.
- Steelers vs. Jets could not be more popcorn-emoji worthy. Rodgers' tenure with the Jets was a complete disaster, but the 41-year-old is out to prove he has something left in the tank. Oh, and Justin Fields, who's now under centre in the Meadowlands, can also call "revenge game" against Mike Tomlin's group, which cast him aside for Russell Wilson last season.
- Let's circle back to the week's biggest matchup: Ravens vs. Bills. Buffalo went undefeated at home last year and eliminated Baltimore from the playoffs in a nailbiter at Highmark Stadium. The last two MVPs will be eager to make a statement in a Sunday Night Football pick'em.
- Cam Ward, the 2025 first overall pick, has the toughest landing spot imaginable: a road date with the Denver Broncos. The Tennessee Titans are 8.5-point 'dogs against last year's No. 3 scoring defence.
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Week 1 betting notes
- Speaking of Ward, rookie quarterbacks making their first start on the road haven't fared well since the 1970 NFL merger (8-21 straight up, 3-14-2 ATS, per Action Network). JJ McCarthy, while not technically a rookie, is making his first start for the Minnesota Vikings on the road versus the Chicago Bears — on Monday Night Football.
- Joe Burrow and the Cincinnati Bengals need to start this season off on the right foot, but can they? Cincy is 1-4 SU and ATS in Burrow's season openers. The Bengals are 5-point road favourites in Cleveland.
- Divisional underdogs are 40-41-2 SU in Week 1 since 2010. Divisional home underdogs are 23-7 ATS in that same span. Cleveland falls into that latter category alongside Seattle, Chicago and Atlanta.
- Austin Ekeler tops the depth chart in a crowded Washington Commanders running back room. He should be a player to watch against the New York Giants, who allowed the fifth-most rushing and seventh-most receiving yards per game to RBs last year.
- Last year, favourites went 13-3 SU and 9-7 ATS in Week 1. But that was only the second time since 2019 that favourites came out ahead ATS in the first weekend, also going 9-7 in 2020.
Biggest spreads: Cowboys vs. Eagles (-8.5), Titans vs. Broncos (-8), Cardinals (-6.5) vs. Saints
Highest totals: Ravens vs. Bills (50.5), Bengals vs. Browns (47.5), Buccaneers vs. Falcons (47.5)
NFL betting guide: Week 1 predictions
Week 1 best bets: Two player props, a moneyline prediction and three ATS picks make up this six-pack of Week 1 best bets. Among the featured: Christian McCaffrey and the San Francisco 49ers.
Week 1 ATS picks: Get ATS predictions for the entire slate, headlined by Ravens vs. Bills on Sunday Night Football.
Week 1 prop picks: A trio of player props from three different Week 1 games. Find out how Avery Perri is betting on Marvin Harrison Jr., David Montgomery and Cedric Tillman.
Ravens vs. Bills SNF picks: Sunday night can't come soon enough! Buffalo bounced Baltimore from the postseason last year, and revenge is sure to be on Jackson and Co.'s mind. Perri is fading the Bills while backing Derrick Henry.
Week 1 TD picks: Who will find the end zone in Week 1? Closs made three picks, featuring running back Nick Chubb in his first game with the Houston Texans.
Lions vs. Packers SGP picks: Two NFC North rivals start their seasons with a Sunday afternoon clash. Check out this +310 SGP that features RBs Josh Jacobs and Jahmyr Gibbs.
Steelers vs. Jets SGP picks: Who will come out on top in this double-sided revenge game? Perri says Pittsburgh and expects T.J. Watt to be a force on defence.
Ravens vs. Bills SGP picks: It's a rematch from last year's AFC divisional round. Steven Psihogios is betting on a bounce back from Mark Andrews in a +650 ticket.
Vikings vs. Bears picks: The J.J. McCarthy bandwagon is full, but Psihogios says not so fast. He's fading the Minnesota QB and backing Chicago to win on Monday Night Football.
We'll release more NFL predictions over the weekend. Here's what you can expect leading into the first Football Sunday of the season!
Sept. 7
- Ravens vs. Bills TD picks
- Vikings vs. Bears SGP picks
NFL betting guide: 2025 futures focus
There's still time to get your futures bets in and get caught up before the 2025 season kicks off. Here's a good place to start:
NFL season preview: This has everything you need to get dialled in. Freshen up on which rookies to watch, futures markets, offseason moves and more!
Super Bowl best bets: Buffalo has experienced nothing but pain in the playoffs since Allen took over at quarterback, but that doesn't mean it should be overlooked. Read why this will be the year for Bills Mafia.
MVP & ROTY predictions: Jackson and Allen top the NFL MVP odds board, and for good reason. But our staff is looking elsewhere this season, and they also have three picks on who can take home Rookie of the Year honours.
Long shot futures picks: A tight end has never won NFL Offensive Player of the Year. But Horrobin sees a path for that to change. Find out who he's backing, plus check out a 60-to-1 MVP recommendation.
NFL division winners: Will the AFC West have a new champion in 2025? Our Spencer Closs thinks so. We're also giving out a four-leg divisional parlay, with juicy 45-to-1 odds.
NFL Week 1 matchups
Thursday Night Football (Sept. 4)
- Cowboys vs. Eagles (8:20 p.m. ET)
Friday, Sept. 5 (in Brazil)
- Chiefs vs. Chargers (8 p.m. ET)
Sunday, Sept. 7: 1 p.m. ET slate
- Cardinals vs. Saints | Panthers vs. Jaguars | Bengals vs. Browns | Raiders vs. Patriots
- Dolphins vs. Colts | Giants vs. Commanders | Steelers vs. Jets | Buccaneers vs. Falcons
Sunday, Sept. 7: 4 p.m. ET slate
- 49ers vs. Seahawks | Titans vs. Broncos | Lions vs. Packers | Texans vs. Rams
Sunday Night Football
- Ravens vs. Bills (8:20 p.m. ET)
Monday Night Football (Sept. 8)
- Vikings vs. Bears (8:15 p.m. ET)
