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MLB home run picks Sept. 17: Back Jakob Marsee, George Springer on Wednesday

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Check out Wednesday's top MLB home run picks! Photos by AP.

Toronto Blue Jays slugger George Springer headlines Wednesday's MLB home run picks.

Today's MLB HR narrative: Springer has been one of the best players in baseball since the all-star break and has solid value to go deep against Tampa Bay Rays reliever-turned-starter Ian Seymour.

Check out the best MLB home run picks and analysis for Sept. 17, featuring a pick on Jakob Marsee.

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MLB home run picks

Best Bet: Springer to hit a home run (+360)

Springer is having his best season as a Blue Jay, and arguably the best season of the second half of his career.

Just look at what the veteran outfielder has done since the all-star break (MLB ranks in parentheses):

  • .372 BA (1st)
  • .667 SLG (2nd)
  • 210 wRC+ (1st)
  • .295 ISO (12th)

Springer has 13 home runs in that 39-game stretch, and three of those came against southpaws in 35 plate appearances.

Tampa Bay's Seymour is making his fourth MLB start and his first at home.

Things haven't gone so well for the lefty at George M. Steinbrenner Field, the Rays' temporary home venue, in his outings as a reliever.

In 12.2 IP, Seymour has allowed a .296 opponent batting average and three home runs.

That shouldn't be too surprising though, because George M. Steinbrenner Field ranks as the second-most HR-friendly venue for righty bats (33% more than league average).

Key stat: Springer is slashing .345/.457/.690 against LHPs in the second half.

Best HR predictions

Marsee to hit a home run (+510): Speaking of offence-friendly venues, Colorado's Coors Field is the cream of the crop.

The mile-high ballpark has been the best offensive environment in baseball over the last three seasons.

Marsee, who has been crushing it as a rookie for the Miami Marlins, got his first taste of Coors last night, and he delivered.

He went 1-for-5 with a double and cashed two RBIs in a 6-5 win.

The lefty bat goes up against fellow rookie, right-hander McCade Brown, tonight, and he's gotten lit up at home (14.29 ERA).

Brown just allowed five hits and six earned runs (one HR) in 1.2 IP at Coors Field on Sept. 6.

Marsee is slashing .311 with a .509 slugging percentage against righties this year.

MLB home run picks made at 11:55 a.m. ET on 09/17/2025.

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