After cashing a +318 parlay last week, let's run it back with some Week 3 college football predictions.
The pregame narrative: After an early bye, the Notre Dame Fighting Irish are back at it in another ranked-on-ranked showdown against the Texas A&M Aggies. The Irish have a stellar running game that should lead to plenty of offensive success.
Check out my college football parlay predictions for Week 3, featuring a pick on the Florida Gators vs. LSU Tigers game.
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College football predictions: Week 3 parlay
Parlay: Notre Dame over 27.5 points | LSU -3.5 | Vanderbilt +7.5 (+333)
Notre Dame over 27.5 points (-125): No. 8 Notre Dame didn't quite get to this number in a 23-13 win over Texas A&M last year, but I'm a big fan of the matchup stylistically for the Fighting Irish.
Notre Dame loves to run the ball, and there are signs that that could work well against No. 16 Texas A&M.
- TAMU allowed 203 rushing yards on 6.4 yards/carry in Week 1 vs. the University of Texas at San Antonio (UTSA).
- Through two games, the Aggies rank 111th out of 134 NCAA Division I schools in EPA per rush, according to Game On Paper.
The Irish have arguably the most enviable backfield in the country with Jeremiyah Love and Jadarian Price. The tandem rushed for 135 yards on 6.1 YPC against the Aggies last year.
Notre Dame averaged 36.1 PPG in 2024, which ranked 10th in D-I.
NCAAF parlay picks
LSU -3.5 (-195): Florida lost at home last week as an 18-point favourite and now has to go to Death Valley for a night game. Good luck with that.
The Gators beat the Tigers at home last year, but LSU did everything it could to lose that game. LSU doubled up Florida in time of possession, but also fumbled three times and missed a field goal.
Florida quarterback DJ Lagway was only 13-for-26 passing with one touchdown, and if No. 3 LSU can hold him down again, I really like the team's chances to win.
The Tigers have won five straight games by seven or more points dating back to last year, including a road win over then-No. 4 Clemson in Week 1.
Vanderbilt +7.5 (-190): If you aren't a Diego Pavia believer by now, I don't know what to tell you.
Pavia led the Vanderbilt Commodores to their first bowl win in over a decade last year, collecting some impressive upset wins along the way. They beat then-No. 1 Alabama, along with Kentucky, Auburn and Virginia Tech.
- Since the start of last season, Vanderbilt is 6-5 SU as an underdog and 9-2 ATS.
- The Commodores have covered a +7.5 line in 12 of their past 14 games.
To cash this bet, Pavia will need to be better against the South Carolina Gamecocks than he was in last year's matchup (231 total yards, one TD). But I think he can get it done.
Especially because No. 11 South Carolina hasn't been anything special so far this year.
The Gamecocks beat Virginia Tech, 24-11, in their opener ... but the Commodores beat that same Va. Tech squad last week, 44-20.
College football predictions made at 2:10 p.m. on 09/11/2025.
